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Fig. 1 | Evolution: Education and Outreach

Fig. 1

From: The Double-Edged Sword: How Evolution Can Make or Break a Live-Attenuated Virus Vaccine

Fig. 1

a The Pastorian approach for attenuation by serial passage b Passage history of three live-attenuated virus vaccines derived by serial passage: the yellow fever virus 17D vaccine strain (Monath et al. 2008), the cold-adapted influenza A/Ann Arbor/6/60 vaccine strain (Maassab and DeBorde 1985), and the chickenpox (varicella) Oka vaccine strain (Hambleton and Gershon 2005; Takahashi et al. 2008)

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